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FLASH GENE

Symbol

SP3

contributors: mct - updated : 31-01-2015

HGNC name	Sp3 transcription factor
HGNC id	11208

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003111 7 splicing 6359 NP_003102 81 781 - 2006 16781829 full length of Sp3 weak to moderate activator of SRC NM_001017371 5 splicing 6008 NP_001017371 75 713 - 2006 16781829 N-terminally truncated version of Sp3 Up to five times more active than variant 1 NM_001172712 7 - 6350 NP_001166183 - 778 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Endocrine parathyroid       highly Lymphoid/Immune lymph node       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a long serine/threonine and glutamine rich region (transactivation domain) at the N terminus
	a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
	a DNA binding domain of three zinc fingers of the C2H2 type near the C terminus
	a negative regulatory domain present in the C-terminus modulating its protein levels and activation of the CDKN1A promoter

HOMOLOGY

interspecies	homolog to rattus Sp3 (95,37 pc)
	homolog to murine Sp3 (97,42 pc)

Homologene

FAMILY

Sp1 family of zinc-finger GC box binding transcription factor

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	repressor of SP1-mediated transcriptional activation
	SP1 and SP3 may function as the main regulator of the basal and serum-induced transcription of CENPW
	function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes
	plays likely a major role in the inhibitory effect of glutamine on apoptosis
	SP3 plays potentially a key role in the expression of NOX4 in various cell lineages in humans
	regulation of trefoil factor 2 expression by the transcription factor SP3
	more or less transactivator activity, depending on the sumoylation
	novel role for SP3 in sarcomas as a driver for expression of the metastasis-related gene AFAP1L1
	promote the binding of protein phosphatase 1 (PP1) to the CDKN1A promoter, leading to reduced H3S10 phosphorylation, a finding consistent with SP3-dependent regulation of the local balance between kinase and phosphatase activities

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to GT box regulatory elements

RNA

small molecule

protein	associating with the endogenously repressed TERT (telomerase reverse transcriptase) recruiting histone deacetylase(s) for the localized deacetylation of nucleosomal histones ans silencing of TERT in normal somatic cells
	repressing the SP1 mediated transactivation of COL2A1 in chondrocytes
	CENPW induced by serum stimulation followed by serum deprivation, with SP1 and SP3 transcription factors involved in this transactivation
	proximal FOXP3 promoter transactivation was inhibited by FOXP3 and the SP transcription factor family member SP3
	functional synergy of SP1, SP3, SP4 with the photoreceptor-enriched CRX transcriptional regulator on the rod opsin promoter but not the beta-PDE promoter, although SP4-mediated activation was the most significant
	transcription factor SP1 and SP3 up-regulate the basal transcriptional activity of CD2AP and increase CD2AP expression at mRNA level
	basal expression level of IRF3 is regulated by transcription factors SP1 and SP3
	major regulator of TFF2 expression
	inhibition of FGF10 by inflammatory signaling involves the NFKB1-dependent interactions between RELA, SP3, and the FGF10 promoter
	SP1 and SP3 are functionally involved as transcriptional integrators regulating the basal expression of the derived EPHX1 E1b variant transcript
	SP1/SP3 transcription factors trigger MINA expression through additive activity targeted to a cluster of four SP1/SP3 binding sites forming the P1 promoter

cell & other

REGULATION

Other

modified by SUMO-1

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q31

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS