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FLASH GENE
Symbol SP3 contributors: mct - updated : 31-01-2015
HGNC name Sp3 transcription factor
HGNC id 11208
Corresponding disease
DEL2Q31 chromosome 2q interstitial deletion, including 2q31.1
Location 2q31.1      Physical location : 174.771.187 - 174.830.430
Synonym name
  • specificity protein 3
  • GC-binding transcription factor Sp3
    • Synonym symbol(s) SPR-2, DKFZp686O1631, SPR2
    DNA
    TYPE functioning gene
    STRUCTURE 59.24 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • binding strongly to GC and GT-box regulatory elements
  • 5'-flanking region of the Sp3 gene, contains Sp1/Sp3 binding sites
    • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 6359 81 781 - 2006 16781829
  • full length of Sp3
  • weak to moderate activator of SRC
    • 5 splicing 6008 75 713 - 2006 16781829
  • N-terminally truncated version of Sp3
  • Up to five times more active than variant 1
    • 7 - 6350 - 778 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long serine/threonine and glutamine rich region (transactivation domain) at the N terminus
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • a DNA binding domain of three zinc fingers of the C2H2 type near the C terminus
  • a negative regulatory domain present in the C-terminus modulating its protein levels and activation of the CDKN1A promoter
    • HOMOLOGY
    interspecies homolog to rattus Sp3 (95,37 pc)
    homolog to murine Sp3 (97,42 pc)
    Homologene
    FAMILY
  • Sp1 family of zinc-finger GC box binding transcription factor
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • repressor of SP1-mediated transcriptional activation
  • SP1 and SP3 may function as the main regulator of the basal and serum-induced transcription of CENPW
  • function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes
  • plays likely a major role in the inhibitory effect of glutamine on apoptosis
  • SP3 plays potentially a key role in the expression of NOX4 in various cell lineages in humans
  • regulation of trefoil factor 2 expression by the transcription factor SP3
  • more or less transactivator activity, depending on the sumoylation
  • novel role for SP3 in sarcomas as a driver for expression of the metastasis-related gene AFAP1L1
  • promote the binding of protein phosphatase 1 (PP1) to the CDKN1A promoter, leading to reduced H3S10 phosphorylation, a finding consistent with SP3-dependent regulation of the local balance between kinase and phosphatase activities
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to GT box regulatory elements
    RNA
    small molecule
    protein
  • associating with the endogenously repressed TERT (telomerase reverse transcriptase) recruiting histone deacetylase(s) for the localized deacetylation of nucleosomal histones ans silencing of TERT in normal somatic cells
  • repressing the SP1 mediated transactivation of COL2A1 in chondrocytes
  • CENPW induced by serum stimulation followed by serum deprivation, with SP1 and SP3 transcription factors involved in this transactivation
  • proximal FOXP3 promoter transactivation was inhibited by FOXP3 and the SP transcription factor family member SP3
  • functional synergy of SP1, SP3, SP4 with the photoreceptor-enriched CRX transcriptional regulator on the rod opsin promoter but not the beta-PDE promoter, although SP4-mediated activation was the most significant
  • transcription factor SP1 and SP3 up-regulate the basal transcriptional activity of CD2AP and increase CD2AP expression at mRNA level
  • basal expression level of IRF3 is regulated by transcription factors SP1 and SP3
  • major regulator of TFF2 expression
  • inhibition of FGF10 by inflammatory signaling involves the NFKB1-dependent interactions between RELA, SP3, and the FGF10 promoter
  • SP1 and SP3 are functionally involved as transcriptional integrators regulating the basal expression of the derived EPHX1 E1b variant transcript
  • SP1/SP3 transcription factors trigger MINA expression through additive activity targeted to a cluster of four SP1/SP3 binding sites forming the P1 promoter
    • cell & other
    REGULATION
    Other modified by SUMO-1
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q31
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS