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FLASH GENE
Symbol CYP21A2 contributors: mct - updated : 26-05-2015
HGNC name cytochrome P450, family 21, subfamily A, polypeptide 2
HGNC id 2600
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure
  • exhibits the characteristic triangular prism shape, containing 16 helices and 9 beta-sheets
    • conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily XXIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • catalyzing the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids
  • its activities, which are required for cortisol and aldosterone biosynthesis, involve the formation of energetically disfavored primary carbon radical
  • CYP17A1 and CYP21A2 are required for the biosynthesis of androgens, glucocorticoids, and mineralocorticoids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    text oxidative metabolism
    PATHWAY
    metabolism drug , hormone
    signaling
  • adrenocortical steroid biosynthesis including cortis and aldosterone
    • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CYP21A2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS