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FLASH GENE

Symbol

CSF2

contributors: mct - updated : 28-01-2019

HGNC name	colony stimulating factor 2 (granulocyte-macrophage)
HGNC id	2434

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased pulmonary CSF2 production in response to infection is primed by the microbiota through IL17A constitutional       gain of function in periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy syndrome with activation of IL8

Susceptibility

to asthma to rheumatoid arthritis

Variant & Polymorphism	variant ile 117 maybe a risk factor for atopic asthma

Candidate gene
Marker
Therapy target	antibody specific for cytokine or receptor as therapeutic targets in rheumatoid arthritis

ANIMAL & CELL MODELS

in Csf2 gene-deficient mice, a detailed kinetic analysis of monocyte/macrophage and neutrophil dynamics in antigen-induced peritonitis suggested that Csf2 was acting, in part, systemically to maintain the inflammatory reaction