| basic FUNCTION
| ligand activated protein-tyrosine kinase that utilizes autophosphorylation sites to regulate kinase activity and to control interactions with signaling proteins |
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disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism and could contribute to invasive progression in epithelial cancers  |
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undergoes regulated intramembrane proteolysis, releasing the intracellular domain from the plasma membrane, enabling it to move to other compartments within the cell to participate in signaling |
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tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis |
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CSF1R, through GAB2, utilizes different effectors at different stages of mononuclear phagocytes development to promote their expansion |
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required for the development of microglia, for a fully functional olfactory system and the maintenance of normal brain structure |
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presence of functional nucleus-associated CSF1Rs, which are activated by extracellular CSF1 by a mechanism that involves PIK3CA and RAB5 activity |
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is a crucial mediator of microglial proliferation and differentiation in the brain |
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directly regulates the development of Paneth cells (PC) and influences proliferation and cell fate in the small intestine |
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CSF1R signaling plays potentially an important role in colon homeostasis and stem cell gene expression |
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CSF1R was involved in the maintenance of adult microglia and the receptor for the cytokine TGFB1 suppressed activation of microglia |
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plays key roles in regulating development and function of the monocyte/macrophage lineage, including microglia and osteoclasts |
