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FLASH GENE

Symbol

C4B

contributors: - updated : 15-01-2007

HGNC name	complement component 4B (Childo blood group)
HGNC id	1324

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   salivary gland       predominantly Nervous nerve

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a N terminal alpha 2 macroglobulin domain
	an anaphylotoxin like domain
	a netrin C terminal domain

conjugated

GlycoP

mono polymer

trimer

isoforms

Precursor

proteolytically cleaved into alpha, beta, gamma chains before secretion

HOMOLOGY

interspecies

ortholog to rattus C4a

Homologene

FAMILY

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	C4 anaphylotoxin, local mediator of inflammation
	classical pathway of C3 activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

binding the immune complex at the cell surface

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

C4B

Susceptibility

to systemic lupus erythematosus (SLE)

Variant & Polymorphism SNP	increasing the risk of systemic lupus erythematosus (SLE)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS