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FLASH GENE
Symbol C4A contributors: - updated : 27-07-2006
HGNC name complement component 4A
HGNC id 1323
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a N terminal alpha 2 macroglobulin domain
  • an anaphylotoxin-like domain
  • a netrin C terminal domain
    • conjugated GlycoP
    mono polymer trimer
    isoforms Precursor proteolytically cleaved into alpha, beta, gamma chains before secretion
    HOMOLOGY
    interspecies ortholog to rattus C4a
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • classical pathway of C3 activation
  • C4a local mediator of inflammation (anaphylatoxin)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component C4 complexing with C2 in the vicinity of C1s
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • C4b binding covalently the immune complex at the cell surfaces
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C4A , RG
    Susceptibility to systemic lupus erythematosus (SLE)
    Variant & Polymorphism other both zero copies and one copy of C4A were risk factors for SLE
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS