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FLASH GENE
Symbol C4A contributors: - updated : 27-07-2006
HGNC name complement component 4A
HGNC id 1323
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineadrenal gland    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a N terminal alpha 2 macroglobulin domain
  • an anaphylotoxin-like domain
  • a netrin C terminal domain
    • conjugated GlycoP
    mono polymer trimer
    isoforms Precursor proteolytically cleaved into alpha, beta, gamma chains before secretion
    HOMOLOGY
    interspecies ortholog to rattus C4a
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • classical pathway of C3 activation
  • C4a local mediator of inflammation (anaphylatoxin)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component C4 complexing with C2 in the vicinity of C1s
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • C4b binding covalently the immune complex at the cell surfaces
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C4A , RG
    Susceptibility to systemic lupus erythematosus (SLE)
    Variant & Polymorphism other both zero copies and one copy of C4A were risk factors for SLE
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS