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FLASH GENE

Symbol

C4A

contributors: - updated : 27-07-2006

HGNC name	complement component 4A
HGNC id	1323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine adrenal gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	a N terminal alpha 2 macroglobulin domain
	an anaphylotoxin-like domain
	a netrin C terminal domain

conjugated

GlycoP

mono polymer

trimer

isoforms

Precursor

proteolytically cleaved into alpha, beta, gamma chains before secretion

HOMOLOGY

interspecies

ortholog to rattus C4a

Homologene

FAMILY

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	classical pathway of C3 activation
	C4a local mediator of inflammation (anaphylatoxin)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

signal transduction

a component

C4 complexing with C2 in the vicinity of C1s

INTERACTION

DNA

RNA

small molecule

protein

cell & other

C4b binding covalently the immune complex at the cell surfaces

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

C4A , RG

Susceptibility

to systemic lupus erythematosus (SLE)

Variant & Polymorphism other	both zero copies and one copy of C4A were risk factors for SLE

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS