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FLASH GENE
Symbol CFB contributors: mct - updated : 25-04-2007
HGNC name complement factor B
HGNC id 1037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one single chain, glycine-rich domain
  • one peptidase S1 domain
  • three Sushi (CCP/SCR) domains
  • one Von Willebrand factor type A domain
    • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine H2-Bf
    ortholog to rattus bf
    Homologene
    FAMILY peptidase S1 family
    CATEGORY enzyme , immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • implicated in proliferation and differentiation of preactivated B lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes
  • Ba inhibits the proliferation of preactivated B lymphocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text complement alternative pathway
    PATHWAY
    metabolism
    signaling
    a component active subunit Bb complexing with C3b to form an alternative pathway C3 convertase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HUS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS