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FLASH GENE
Symbol CFB contributors: mct - updated : 25-04-2007
HGNC name complement factor B
HGNC id 1037
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Reproductivefemale systemuterus  highly
 female systemovary   
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one single chain, glycine-rich domain
  • one peptidase S1 domain
  • three Sushi (CCP/SCR) domains
  • one Von Willebrand factor type A domain
    • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine H2-Bf
    ortholog to rattus bf
    Homologene
    FAMILY peptidase S1 family
    CATEGORY enzyme , immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • implicated in proliferation and differentiation of preactivated B lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes
  • Ba inhibits the proliferation of preactivated B lymphocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text complement alternative pathway
    PATHWAY
    metabolism
    signaling
    a component active subunit Bb complexing with C3b to form an alternative pathway C3 convertase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HUS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS