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FLASH GENE

Symbol

CFB

contributors: mct - updated : 25-04-2007

HGNC name	complement factor B
HGNC id	1037

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2574 85.5 764 - Cislo variant 2 - splicing 1866 - 621 - Cislo

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Reproductive female system uterus     highly   female system ovary       Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one single chain, glycine-rich domain
	one peptidase S1 domain
	three Sushi (CCP/SCR) domains
	one Von Willebrand factor type A domain

conjugated

GlycoP

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine H2-Bf
	ortholog to rattus bf

Homologene

FAMILY

peptidase S1 family

CATEGORY

enzyme , immunity/defense , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	implicated in proliferation and differentiation of preactivated B lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes
	Ba inhibits the proliferation of preactivated B lymphocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	complement alternative pathway

PATHWAY

metabolism

signaling

a component

active subunit Bb complexing with C3b to form an alternative pathway C3 convertase

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HUS2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS