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FLASH GENE

Symbol

ADRB2

contributors: mct - updated : 09-03-2016

HGNC name	adrenergic, beta-2-, receptor, surface
HGNC id	286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function is potentially implicated in diabetic cardiomyopathy constitutional     --over   in lymphatic malformations constitutional     --over   ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease

Susceptibility

to nocturnal asthma, to non insulin dependent diabetes to type 2 diabetes mellitus (T2DM) in obese, postmenopausal women to chronic obstructive pulmonary disease (COPD)

Variant & Polymorphism SNP , other	polymorphism, R16G
	27 Glu polymorphism interacting with physical activity to influence female obesity risk
	Gln27Gln polymorphism increases the risk of non insulin dependent diabetes
	Arg16Gly influencing the pathophysiology of OAG in Japanese patients
	ADRB2 haplotypes may mediate insulin action, glucose tolerance, and potentially risk for type 2 diabetes mellitus (T2DM) in obese, postmenopausal women
	Gly16 allele of ADRB2 predisposes to COPD development but not for exacerbation rates and disease severity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     ADRB2 agonist ameliorates cardiac dysfunction suggesting that ADRB2 have crucial role in diabetic cardiomyopathy

ANIMAL & CELL MODELS