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FLASH GENE

Symbol

ADRB2

contributors: mct - updated : 09-03-2016

HGNC name	adrenergic, beta-2-, receptor, surface
HGNC id	286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.04 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	see CSF1R ,IRF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000024 1 - 2058 - 413 - 1997 9339364

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Nervous brain hindbrain medulla oblongata     Reproductive female system placenta       Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum cardiac     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Muscular myocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a PDZ binding motif
	C terminus distal to AA 381 does not affect the initial interaction between receptor and beta-arrestin, but its last eight AAs facilitate receptor internalization in concert with ARRB2 (

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	major lipolytic receptor in human fat cell, activating adenylate cyclase
	ADRB2, ADRA1B in bone cells may play a role in modulation of bone turnover by the sympathetic nervous system
	seven transmembrane segments (7TM) receptor, polymorphic, with a 5' leader region made of a short ORF, potentially involved in the regulation of cellular ADRBL expression
	mediating the catecholamine-induced activation of adenylate cyclase through the action of G proteins
	may be involved in the cardioprotection against ischemic damage, and the cardioprotection may depend on estrogenic environment
	playing an essential role in signaling and trafficking in cardiac myocytes
	on the surface of cardiomyocytes mediate distinct effects on cardiac function and the development of heart failure by regulating production of the second messenger cyclic adenosine monophosphate (cAMP)
	potential involvement in diabetic cardiomyopathy
	mediates obesity, cardiorespiratory fitness, and insulin resistance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with NEDD4 (NEDD4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the ADRB2)
	ADRB2 is a novel target of PPARgamma transcriptional repression in vascular smooth muscle cells (PPARgamma regulation of ADRB2 signaling is important in the modulation of blood pressure)
	MARCH2 catalytic activity is not required for its interaction with the ADRB2 and loss of activity creates a “substrate trap” leading to a stable complex formation between the two molecules
	ADRB2 stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells
	interaction between RNF5 and the ADRB2 as well as the prostaglandin D2 receptor (DP)
	SSTR2 plays a crucial role in modulation of ADRB1 and ADRB2 mediated signaling pathways that are associated with increased intracellular Ca(2+) and cardiac complications
	ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2

cell & other

REGULATION

Other

is modified at a second site within the third intracellular loop

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function is potentially implicated in diabetic cardiomyopathy constitutional     --over   in lymphatic malformations constitutional     --over   ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease

Susceptibility

to nocturnal asthma, to non insulin dependent diabetes to type 2 diabetes mellitus (T2DM) in obese, postmenopausal women to chronic obstructive pulmonary disease (COPD)

Variant & Polymorphism SNP , other	polymorphism, R16G
	27 Glu polymorphism interacting with physical activity to influence female obesity risk
	Gln27Gln polymorphism increases the risk of non insulin dependent diabetes
	Arg16Gly influencing the pathophysiology of OAG in Japanese patients
	ADRB2 haplotypes may mediate insulin action, glucose tolerance, and potentially risk for type 2 diabetes mellitus (T2DM) in obese, postmenopausal women
	Gly16 allele of ADRB2 predisposes to COPD development but not for exacerbation rates and disease severity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     ADRB2 agonist ameliorates cardiac dysfunction suggesting that ADRB2 have crucial role in diabetic cardiomyopathy

ANIMAL & CELL MODELS