basic FUNCTION
| acting as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane |
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required for insulin-stimulated increase in glucose uptake and glycogen synthesis |
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PIK3R1, PIK3R2 modulate PI 3-kinase-dependent signaling by multiple mechanisms and transmit signals independent of PI 3-kinase activation |
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is likely a determining factor in ICOS-mediated PI3K activity in T cells |
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PIK3R1 and PIK3CB are essential for androgen-stimulated androgen receptor transactivation, and their aberrant expression or activation might play an important role in prostate cancer progression |
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critical regulators of various cellular process including cell survival, growth, proliferation, and motility |
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PIK3R1 regulatory isoform has partially overlapping functions with PIK3R1 in B cells as well as a unique role in opposing BCR responses |
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plays an important role in regulating many cellular processes including cell growth, survival, proliferation, and motility |
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its expression plays a critical role in mediating adipose tissue (AT) insulin sensitivity, suggesting that reduced PIK3R1 activity is a key step in the initiation and propagation of the inflammatory response in obese AT |
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is a highly dynamic molecule whose conformational flexibility allows it to transiently associate with multiple binding proteins |
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novel role of PIK3R1 that was independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids |