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FLASH GENE

Symbol

HIVEP2

contributors: mct - updated : 18-09-2017

HGNC name	human immunodeficiency virus type I enhancer binding protein 2
HGNC id	4921

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRD43

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly depressed in the high malignancy gliomas group (WHO grade IV)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy
	deletion of Shn2 and Shn3 in mice impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation
	Hivep2-knockout mice exhibit several working memory deficits, increased anxiety, and hyperactivity