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FLASH GENE
Symbol KRT13 contributors: mct/npt - updated : 15/09/2008
HGNC name keratin 13
HGNC id 6415
Corresponding disease
WHSN2 white sponge nevus of Cannon, 2
Location 17q21-q22      Physical location : 39.657.232 - 39.661.865
Synonym name
  • keratin, type I cytoskeletal 13
  • cytokeratin 13
  • Synonym symbol(s) K13, CK13, MGC3781, MGC161462
    DNA
    TYPE functioning gene
    STRUCTURE 4.63 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    KRTAP9P1 17q12-q21 keratin associated protein 9 pseudogene 1 LOC390794 17 similar to keratin associated protein 4-12; keratin associated protein 4.12 KRTAP16-1 17q12-q21 keratin associated protein 16-1 KRTAP17-1 17q12-q21 keratin associated protein 17-1 KRTHA3A 17q12-q21 keratin, hair, acidic, 3A KRTHA3B 17q12-q21 keratin, hair, acidic, 3B KRTHA4 17q12-q21 keratin, hair, acidic, 4 KRTHA1 17q12-q21 keratin, hair, acidic, 1 KRTHAP1 17q12-q21 keratin, hair, acidic, pseudogene 1 KRTHA7 17q12-q21 keratin, hair, acidic, 7 KRTHA8 17q12-q21 keratin, hair, acidic, 8 KRTHA2 17q12-q21 keratin, hair, acidic, 2 KRTHA5 17q12-q21 keratin, hair, acidic, 5 KRTHA6 17q12-q21 keratin, hair, acidic, 6 KRT13 17q21-q22 keratin 13 KRT15 17q21.2 keratin 15 KRT19 17q21 keratin 19 KRT9 17q21.1-q21.2 keratin 9 (epidermolytic palmoplantar keratoderma) KRT14 17q21-q22 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) KRT16 17q21-q22 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) KRT17 17q21-q22 keratin 17 LOC388385 17 LOC388385
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1719 49.6 458 - Schweizer (2006)
    - - 1693 45.5 420 - Schweizer (2006)
    early stop codon
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus    
    Digestiveintestinelarge intestineanus  
     mouth    
    Nervousbrain   highly
    Olfactoryolfactory bulb    
    Reproductivefemale systemvagina   
     male systemprostate  highly
    Respiratorynose    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved central rod domain
  • four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2), major acidic keratin, type I
  • HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • structural constituent of cytoskeleton involved in the epidermal differentiation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text epidermal
    PATHWAY
    metabolism
    signaling
    a component
  • associating with KRT4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WHSN2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS