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FLASH GENE

Symbol

DEK

contributors: mct/pgu - updated : 07-02-2018

HGNC name	DEK oncogene
HGNC id	2768

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEK

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma tumoral     --over   in many solid tumors such as colon cancer, larynx cancer, bladder cancer, and melanoma tumoral fusion translocation     t(6;9) chromosomal translocation associated with a subtype of acute myelogenous leukemia (AML), which results in the formation of a DEK-NUP214 fusion protein tumoral     --over gain of function in retinoblastoma tumoral     --over   overexpression in pancreatic ductal adenocarcinoma (PDAC) was correlated with tumor size, histological grade, tumor&8209;node&8209;metastasis (TNM) stage and overall survival (OS) rates

Susceptibility

Variant & Polymorphism

Candidate gene	detection of DEK protein expression should be useful for the diagnosis and prognosis of ovarian serous cancer
	may be a potential biomarker for poor prognostic evaluation in PDAC
Marker
Therapy target
	System Type Disorder Pubmed neurology ataxia   able to partially reverse the mutation-prone phenotype of cells from patients with ataxia telangiectasia cancer reproductive ovary might be a useful molecular target for ovarian cancer therapy cancer     targeted suppression of DEK may become a strategic approach to the treatment of cancer cancer brain   can be used as a potential target for astrocytic tumor gene therapy

ANIMAL & CELL MODELS