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FLASH GENE
Symbol DEK contributors: mct/pgu - updated : 07-02-2018
HGNC name DEK oncogene
HGNC id 2768
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2785 - 341 - 2010 20040570
11 - 2879 43 375 - 2010 20040570
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveesophagus   predominantly
 intestinelarge intestinecolon moderately
 intestinesmall intestine  moderately
 salivary gland   highly
Endocrinethyroid   moderately
Hearing/Equilibriumear   moderately
Lymphoid/Immunethymus   moderately
Reproductivefemale systemuteruscervix highly
 male systemprostate  moderately
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a SAP putative DNA binding domain
  • an acidic domain interacting with histone
  • central and C-terminal regions are highly conserved
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Dek (92.5 pc)
    ortholog to murine Dek (91.4 pc)
    Homologene
    FAMILY
  • DNA-binding SAP family
  • CATEGORY chaperone/stress , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in viral genome replication
  • inducing positive supercoils into closed circular DNA
  • being also involved in splice site selection during mRNA processing
  • nuclear phosphoprotein implicated in oncogenesis and autoimmunity
  • promotes the repair of DNA lesions and protects cells from genotoxic agents that typically trigger poly(ADP-ribose) polymerase activation
  • crucial role of poly(ADP-ribosyl)ation in shaping DEK autoantigenic properties and in its function as a promoter of cell survival
  • suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft models
  • required for intron removal
  • exerting a potent inhibitory effect on both EP300 and PCAF-mediated histone acetyltransferase activity and transcription
  • playing a role in the proliferation of hematopoietic cells
  • DEK-NUP214 fusion protein appears defective, at least in part, in assisting transcriptional regulation of certain genes that might be essential for normal differentiation of hematopoietic cells
  • may be a histone chaperone
  • promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells
  • DEK positively regulates engrafting capability of self-renewing hematopoietic stem (HSCs)
  • CEBPA and DEK coordinately activate myeloid gene expression and S21 phosphorylation on wild-type CEBPA mediates protein interactions that regulate the differentiation capacity of hematopoietic progenitors
  • biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity
  • paracrine loop involving DEK plays a role in chromatin biology
  • identified as one of the most abundant proteins in human chromatin
  • is a unique chromatin architectural factor which binds to non-B-form DNA structures, such as cruciform DNA or four-way junctions
  • facilitates cellular proliferation under conditions of DNA replication stress by promoting replication fork progression
  • plays an important role in cell processes and participates in a variety of cellular metabolic functions, and its altered expression is associated with several human malignancies
  • critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma
  • transcription factor, involved in mRNA splicing, transcriptional control, cell division and differentiation
  • important for DNA double-strand break repair
  • plays multiple roles to facilitate tumor growth and maintenance
  • CELF1 and DEK were found to represent early-induced melanoma genes and adverse indicators of overall patient survival
  • CELLULAR PROCESS nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and THOC4
  • INTERACTION
    DNA binding to cruciform and superhelical DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • histones H2A, H2B, H3, H4, acetylated histone H4
  • non-phosporylated DAXX
  • HDAC2
  • interacting wth SET and PARP1 (constitute a network governing access to chromatin by the transcription machinery)
  • molecular links between DEK and DNA damage response signaling pathways, suggesting that DEK contributes to DNA repair
  • DEK emerges as an TERT repressor shared by various leukemia subtypes and seems involved in the deregulation of numerous genes associated with leukemogenesis
  • is a critical factor that interacts with an essential upstream enhancer element of the KLF1 promoter and exerts a positive effect on KLF1 levels
  • DEK is an unexpected target and downstream effector of CELF1
  • cell & other
  • the (pets) site of the HIV2 enhancer, autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEK
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    tumoral     --over  
    in many solid tumors such as colon cancer, larynx cancer, bladder cancer, and melanoma
    tumoral fusion translocation    
    t(6;9) chromosomal translocation associated with a subtype of acute myelogenous leukemia (AML), which results in the formation of a DEK-NUP214 fusion protein
    tumoral     --over gain of function
    in retinoblastoma
    tumoral     --over  
    overexpression in pancreatic ductal adenocarcinoma (PDAC) was correlated with tumor size, histological grade, tumor&8209;node&8209;metastasis (TNM) stage and overall survival (OS) rates
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • detection of DEK protein expression should be useful for the diagnosis and prognosis of ovarian serous cancer
  • may be a potential biomarker for poor prognostic evaluation in PDAC
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyataxia 
    able to partially reverse the mutation-prone phenotype of cells from patients with ataxia telangiectasia
    cancerreproductiveovary
    might be a useful molecular target for ovarian cancer therapy
    cancer  
    targeted suppression of DEK may become a strategic approach to the treatment of cancer
    cancerbrain 
    can be used as a potential target for astrocytic tumor gene therapy
    ANIMAL & CELL MODELS