| basic FUNCTION
| playing a role in viral genome replication |
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inducing positive supercoils into closed circular DNA |
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being also involved in splice site selection during mRNA processing |
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nuclear phosphoprotein implicated in oncogenesis and autoimmunity  |
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promotes the repair of DNA lesions and protects cells from genotoxic agents that typically trigger poly(ADP-ribose) polymerase activation |
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crucial role of poly(ADP-ribosyl)ation in shaping DEK autoantigenic properties and in its function as a promoter of cell survival |
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suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft models |
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required for intron removal |
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exerting a potent inhibitory effect on both EP300 and PCAF-mediated histone acetyltransferase activity and transcription |
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playing a role in the proliferation of hematopoietic cells |
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DEK-NUP214 fusion protein appears defective, at least in part, in assisting transcriptional regulation of certain genes that might be essential for normal differentiation of hematopoietic cells |
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may be a histone chaperone |
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promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells |
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DEK positively regulates engrafting capability of self-renewing hematopoietic stem (HSCs) |
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CEBPA and DEK coordinately activate myeloid gene expression and S21 phosphorylation on wild-type CEBPA mediates protein interactions that regulate the differentiation capacity of hematopoietic progenitors |
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biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity |
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paracrine loop involving DEK plays a role in chromatin biology |
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identified as one of the most abundant proteins in human chromatin |
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is a unique chromatin architectural factor which binds to non-B-form DNA structures, such as cruciform DNA or four-way junctions |
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facilitates cellular proliferation under conditions of DNA replication stress by promoting replication fork progression |
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plays an important role in cell processes and participates in a variety of cellular metabolic functions, and its altered expression is associated with several human malignancies |
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critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma |
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transcription factor, involved in mRNA splicing, transcriptional control, cell division and differentiation |
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important for DNA double-strand break repair |
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plays multiple roles to facilitate tumor growth and maintenance |
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CELF1 and DEK were found to represent early-induced melanoma genes and adverse indicators of overall patient survival |
