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FLASH GENE

Symbol

RDBP

contributors: mct/npt - updated : 14-06-2008

HGNC name	RD RNA binding protein
HGNC id	13974

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 11 - 1568 43.2 380 - Rao (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           salivary gland       highly Reproductive female system ovary     highly   male system prostate     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a canonical betaalphabetabetaalphabeta RNA recognition motif (RRM) that binds to a wide variety of RNA sequences

conjugated

RiboP

HOMOLOGY

interspecies

homolog to murine D17H6S45

Homologene

FAMILY

RRM NELF-E family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	new factor that coordinates different mRNA processing steps during transcription
	negatively regulate transcription elongation by RNA polymerase II (RNAPII)

CELLULAR PROCESS

nucleotide, transcription, elongation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

interacts with the nuclear cap binding complex (NCBP1), a multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of replication-dependent histone mRNAs

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS