Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VARS2 contributors: mct - updated : 18-05-2018
HGNC name valyl-tRNA synthetase 2, mitochondrial (putative)
HGNC id 21642
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 29
  • a GST C-terminal domain
  • characteristic Rossman fold catalytic domain
    • conjugated Other
    mono polymer heteromer , aggregate
    HOMOLOGY
    interspecies homolog to rattus Vars2l (84.3 pc)
    homolog to murine Vars2 (84.4 pc)
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the aminoacylation of tRNA by their cognate amino acid
  • acting as a valine-tRNA ligase
  • catalyzes the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming high-molecular-mass aggregates with elongation factor 1
    • INTERACTION
    DNA
    RNA binding to tRNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    Other regulated by protein kinase C-dependent phosphorylation
    acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD20
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • VARS2 V552V may be considered as a prognostic factor for survival in patients with early breast cancer
    • Therapy target
    ANIMAL & CELL MODELS