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FLASH GENE

Symbol

VARS2

contributors: mct - updated : 18-05-2018

HGNC name	valyl-tRNA synthetase 2, mitochondrial (putative)
HGNC id	21642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001167734 29 - 3629 NP_001161206 118.3 1063 - 2014 24827421 NM_020442 29 - 3625 NP_065175 - 1063 - 2014 24827421 NM_001167733 29 - 3397 NP_001161205 - 923 - 2014 24827421

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       highly Endocrine pancreas       highly Lymphoid/Immune thymus       moderately Nervous brain       moderately Reproductive female system ovary     moderately   male system prostate       Respiratory lung       highly   respiratory tract trachea     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines
fluid/secretion	predominantly in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 29
	a GST C-terminal domain
	characteristic Rossman fold catalytic domain

conjugated

Other

mono polymer

heteromer , aggregate

HOMOLOGY

interspecies	homolog to rattus Vars2l (84.3 pc)
	homolog to murine Vars2 (84.4 pc)

Homologene

FAMILY

class-I aminoacyl-tRNA synthetase family

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the aminoacylation of tRNA by their cognate amino acid
	acting as a valine-tRNA ligase
	catalyzes the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forming high-molecular-mass aggregates with elongation factor 1

INTERACTION

DNA

RNA	binding to tRNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

Other	regulated by protein kinase C-dependent phosphorylation
	acetylated

ASSOCIATED DISORDERS

corresponding disease(s)

COXPD20

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	VARS2 V552V may be considered as a prognostic factor for survival in patients with early breast cancer
Therapy target

ANIMAL & CELL MODELS