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FLASH GENE

Symbol

ITGA2

contributors: mct - updated : 09-05-2007

HGNC name	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
HGNC id	6137

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       deficiency of platelet receptor for collagen constitutional germinal mutation       fetal and neonatal alloimmune thrombocytopenia [alloantigène Br(a)]

Susceptibility

to prostate cancer and other cancers to coronary atherosclerosis

Variant & Polymorphism SNP	rs3212649 and rs1126643, significantly associated in both familial and sporadic prostate cancer (FitzGerald 2009)
	rs3212556 associated with coronary atherosclerosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS