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FLASH GENE

Symbol

TCF7

contributors: mct - updated : 19-09-2016

HGNC name	transcription factor 7 (T-cell specific, HMG-box)
HGNC id	11639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

asthma to type 1 diabetes (T1D)

Variant & Polymorphism SNP	variant (A) allele of C883A was significantly associated with T1D

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   TCF7 and LEF1 transcription factors are novel therapeutic targets in treating hematological malignancies

ANIMAL & CELL MODELS

	TCF7/mice developing adenomas in the gut and mammary glands
	Tcf1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes