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FLASH GENE
Symbol TCF7 contributors: mct - updated : 19-09-2016
HGNC name transcription factor 7 (T-cell specific, HMG-box)
HGNC id 11639
RNA
TRANSCRIPTS type messenger
text six isoforms produced by alternative splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3277 - 384 - 2011 21814277
9 - 2839 - 269 - 2011 21814277
9 - 3322 - 269 - 2011 21814277
10 - 2935 - 268 - 2011 21814277
8 - 3073 - 269 - 2011 21814277
- - 500 - 20 - 2011 21814277
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
DNA binding protein with an high mobility group (HMG) domain
HOMOLOGY
interspecies homolog to murine Tcf7
homolog to C.elegans f59b10.4
Homologene
FAMILY high mobility group (HMG) family
CATEGORY immunity/defense , regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • playing a role in the establishment of the mature T cell phenotype
  • can function with CTNNB to mediate canonical Wnt signalling; however, deletion of CTNNB does not affect T-cell development
  • initiates T(H)2 differentiation of activated CD4(+) T cells by promoting GATA-3 expression and suppressing IFN-gamma expression
  • its function to establish CD8 T cell memory is dependent on the catenin-binding domain in TCF7 and requires the TCF7 coactivators and Wnt signaling intermediates beta-catenin and gamma-catenin
  • critical player in a transcriptional program that regulates memory CD8 differentiation and longevity
  • critical regulator in T-cell specification
  • marked requirement at very early stages of T-cell development, which was clearly revealed when TCF7-deficient progenitors were placed in competition with TCF7-sufficient cells
  • critical regulator that is not only essential for normal T-cell development but is sufficient to establish many components of T-cell identity
  • TCF7-mediated repression of IL17 is critical for peripheral T cells to generate balanced immune responses
  • required at the earliest phase of T-cell determination for progression beyond the early thymic progenitor stage
  • important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
  • TCF7 and CTNNB1 regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus
  • essential role for TCF7 and LEF1 in development of NKT cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to T lymphocytes specific enhancer element (5'-WWCAAG-3') found in the promoter of the CD3-epsilon gene
    RNA
    small molecule
    protein
  • critical factor to repress IL17 gene locus by chromatin modifications during T cell development
  • TCF7 and RUNX1 bind to each other promoter regions and that TCF7 is necessary for the production of the short isoforms, but not the long isoforms of RUNX1
  • UCHL5 interacts with TCF7 (formerly named Tcf1) to activate Wnt signalling
  • cell & other
    REGULATION
    Other NOTCH1 regulates TCF7 expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • asthma
  • to type 1 diabetes (T1D)
  • Variant & Polymorphism SNP variant (A) allele of C883A was significantly associated with T1D
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    TCF7 and LEF1 transcription factors are novel therapeutic targets in treating hematological malignancies
    ANIMAL & CELL MODELS
  • TCF7/mice developing adenomas in the gut and mammary glands
  • Tcf1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes