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FLASH GENE

Symbol

TCF7

contributors: mct - updated : 19-09-2016

HGNC name	transcription factor 7 (T-cell specific, HMG-box)
HGNC id	11639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	six isoforms produced by alternative splicing

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003202 10 - 3277 NP_003193 - 384 - 2011 21814277 NM_201632 9 - 2839 NP_963963 - 269 - 2011 21814277 NM_001134851 9 - 3322 NP_001128323 - 269 - 2011 21814277 NM_201634 10 - 2935 NP_963965 - 268 - 2011 21814277 NM_213648 8 - 3073 NP_998813 - 269 - 2011 21814277 variant 7 - - 500 - 20 - 2011 21814277

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

DNA binding protein with an high mobility group (HMG) domain

HOMOLOGY

interspecies	homolog to murine Tcf7
	homolog to C.elegans f59b10.4

Homologene

FAMILY

high mobility group (HMG) family

CATEGORY

immunity/defense , regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in the establishment of the mature T cell phenotype
	can function with CTNNB to mediate canonical Wnt signalling; however, deletion of CTNNB does not affect T-cell development
	initiates T(H)2 differentiation of activated CD4(+) T cells by promoting GATA-3 expression and suppressing IFN-gamma expression
	its function to establish CD8 T cell memory is dependent on the catenin-binding domain in TCF7 and requires the TCF7 coactivators and Wnt signaling intermediates beta-catenin and gamma-catenin
	critical player in a transcriptional program that regulates memory CD8 differentiation and longevity
	critical regulator in T-cell specification
	marked requirement at very early stages of T-cell development, which was clearly revealed when TCF7-deficient progenitors were placed in competition with TCF7-sufficient cells
	critical regulator that is not only essential for normal T-cell development but is sufficient to establish many components of T-cell identity
	TCF7-mediated repression of IL17 is critical for peripheral T cells to generate balanced immune responses
	required at the earliest phase of T-cell determination for progression beyond the early thymic progenitor stage
	important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
	TCF7 and CTNNB1 regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus
	essential role for TCF7 and LEF1 in development of NKT cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to T lymphocytes specific enhancer element (5'-WWCAAG-3') found in the promoter of the CD3-epsilon gene

RNA

small molecule

protein	critical factor to repress IL17 gene locus by chromatin modifications during T cell development
	TCF7 and RUNX1 bind to each other promoter regions and that TCF7 is necessary for the production of the short isoforms, but not the long isoforms of RUNX1
	UCHL5 interacts with TCF7 (formerly named Tcf1) to activate Wnt signalling

cell & other

REGULATION

Other

NOTCH1 regulates TCF7 expression

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

asthma to type 1 diabetes (T1D)

Variant & Polymorphism SNP	variant (A) allele of C883A was significantly associated with T1D

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   TCF7 and LEF1 transcription factors are novel therapeutic targets in treating hematological malignancies

ANIMAL & CELL MODELS

	TCF7/mice developing adenomas in the gut and mammary glands
	Tcf1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes