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FLASH GENE

Symbol

ADRA1B

contributors: mct - updated : 12-06-2014

HGNC name	adrenergic, alpha-1B-, receptor
HGNC id	278

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q33.3      Physical location : 159.343.739 - 159.400.017
Synonym symbol(s)	ADRA1, ALPHA1BAR

DNA

TYPE	functioning gene
STRUCTURE	69.05 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000679 2 - 2272 NP_000670 - 520 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart ventricle       Homo sapiens Digestive intestine large intestine colon   moderately Lymphoid/Immune spleen       moderately Reproductive male system testis       Homo sapiens   male system male genital tract epididymis     Homo sapiens   male system seminal vesicles       Homo sapiens   male system prostate       Homo sapiens Respiratory respiratory tract larynx     highly Urinary ureter         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Membrane         Muscular striatum cardiac myocardium   Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM)

conjugated

GlycoP , LipoP

HOMOLOGY

interspecies

ortholog to rattus Adra1b

Homologene

FAMILY	G protein coupled receptor superfamily
	G-protein coupled receptor 1 family

CATEGORY

protooncogene , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	integral to plasma membrane

basic FUNCTION	involved in the control of vascular tone
	mediating its action by association with G proteins that
	activate a phosphatidylinositol-calcium second messenger system
	acting as a rhodopsin-like receptor
	inducing neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines
	ADRB2, ADRA1B in bone cells may play a role in modulation of bone turnover by the sympathetic nervous system.
	regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing vasoconstriction when the endothelium is disrupted

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interactions of alpha(1)-adrenoceptor subtypes with different G proteins elicit the formation of separate signaling cascades, which produce the opposite effects on L-type Ca2+ current (I(Ca))
	S1P was capable of inducing ADRB1 internalization and its autocrine/paracrine generation was relevant for internalization induced by IGF1
	noradrenaline induces binding of CLTA to ADRA1B in the human prostate
	ADRA1B contraction of vascular smooth muscle involves activation of PLD1, which controls a portion of the ADRA1B-induced CACNA1C channel activity

cell & other

REGULATION

Other

IGF1 induces ADRA1B desensitization associated to receptor phosphorylation and internalization

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased in the setting of heart failure

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS