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FLASH GENE

Symbol

MAP1B

contributors: mct/shn - updated : 23-02-2015

HGNC name	microtubule-associated protein 1B
HGNC id	6836

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	102.28 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D5S637 - D5S1491 - MAP1B - D5S650 - D5S357 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005909 7 - 11996 NP_005900 - 2468 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens Adult   brain limbic system hippocampus     Homo sapiens Adult Reproductive male system prostate     highly Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central gray matter   predominantly Homo sapiens Adult Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Adult Visual bipolar cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	prominently expressed during early stages of neuronal development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

MAP1B heavy chain and light chain LC1

secondary structure

three ligh chains LC1, LC2, LC3

HOMOLOGY

interspecies	ortholog to Map1b, Rattus norvegicus
	ortholog to MAP1B, Pan troglodytes
	ortholog to map1b, Danio rerio
	ortholog to Mtap1b, Mus musculus

Homologene

FAMILY

microtubule associated protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
text	coexpressed with GABRR1

basic FUNCTION	microtubule associated protein, involved in neurite outgrow
	involved in the regulation of retrograde axonal transport of mitochondria
	role in adapting microtubules for nerve cell-specific functions
	plays a crucial role in cytoskeleton stability and may also have a role in other cellular functions
	MAP1B-LC1 represses the transcriptional activity of TP53
	contributes to the maintenance of microtubule dynamics
	involved in microtubule assembly, an essential step in neurogenesis
	implicated in regulating microtubule organization and
	dynamics and neuronal polarization
	MAP1B RNA forms an intramolecular G quadruplex structure, which is bound with high affinity and specificity by the FMR1 RGG box
	could be considered as a new protein involved in the terminal differentiation of odontoblasts
	new and crucial function of MAP1B required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization
	implicated in axonal growth and guidance
	new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton
	this activity of MAP1B could contribute to the regulation of synaptic activity and plasticity in the adult brain
	have important roles in neuronal development, particularly during neuronal migration and axonogenesis
	function of MAP1B is to suppress axon branching and enhance axon growth and that this is achieved by maintaining dynamic microtubule growth
	plays an important role in the stability of the cytoskeleton and may have other cellular functions
	neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments
	novel function of MAP1B related with the control of small GTPases

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

protein complex that consists of a heavy chain and light chain (LC1)

INTERACTION

DNA

RNA

small molecule

protein	FMR1 (RNA target of FMR1)
	PAFAH1B1 and participate in neuronal migration
	myelin-associated glycoprotein (MAG) and stathmin-like 2 (STMN2)
	glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
	MAP1B-LC1 an interacting partner of PES1 required for ribosome biogenesis and cell proliferation
	Mapmodulin/leucine-rich acidic nuclear protein (ANP32A)
	GABA(C) rho1 subunit
	gigaxonin (GAN)
	myelin-associated glycoprotein (MAG)
	synuclein, alpha (SNCA)
	Ras association (RalGDS/AF-6) domain family member 1 (RASSF1)
	MAP1B, a microtubule stabilizing protein, and CLTC, the major component of the clathrin triskelion, are interaction partners for DST
	may contribute to the spatiotemporal activation of the Rho-GTPases in dendritic spines by binding to the RAC1 and RhoA GEFs, TIAM1, and ARHGEF2
	MARCH5 interacts with and ubiquitinates mitochondrial MAP1B LC1
	MAP1B facilitates trafficking of SCNA8 to the neuronal cell surface
	MAP1B interaction with the FW Domain of the autophagic receptor NBR1 facilitates its Association to the microtubule network
	MAP1A and MAP1B interact with SNTA1 in the central and peripheral nervous system
	interacts with a guanine exchange factor, termed TIAM1, which specifically activates RAC1
	association between TULP1 and the microtubule-associated protein, MAP1B
	MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway

cell & other

REGULATION

repressed by

FMR1 (inhibition of microtubule -dependent synaptic growth and function)

Other

mitogen-activated protein kinase 8 (MAPK8) a critical regulator of MAP1B activity

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice carrying an insertion in Mtap1b gene die during embryogenesis. Heterozygotes mice exhibit slower growth rates, lack of visual acuity in one or both eyes, and motor system abnormalities. Histochemical analysis revealed abnormalities in Purkinje cell dendritic processes