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FLASH GENE
Symbol MAP1B contributors: mct/shn - updated : 23-02-2015
HGNC name microtubule-associated protein 1B
HGNC id 6836
Location 5q13.2      Physical location : 71.403.117 - 71.505.396
Synonym name
  • FUTSCH, DROSOPHILA, HOMOLOG OF
  • FUTSCH
    • Synonym symbol(s) MAP5, FLJ38954, FUTSCH, DKFZp686E1099; DKFZp686F1345
    DNA
    TYPE functioning gene
    STRUCTURE 102.28 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D5S637 - D5S1491 - MAP1B - D5S650 - D5S357 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 11996 - 2468 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiensAdult
     brainlimbic systemhippocampus   Homo sapiensAdult
    Reproductivemale systemprostate  highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralgray matter predominantly Homo sapiensAdult
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensAdult
    Visualbipolar cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text prominently expressed during early stages of neuronal development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		MAP1B heavy chain and light chain LC1
    secondary structure three ligh chains LC1, LC2, LC3
    HOMOLOGY
    interspecies ortholog to Map1b, Rattus norvegicus
    ortholog to MAP1B, Pan troglodytes
    ortholog to map1b, Danio rerio
    ortholog to Mtap1b, Mus musculus
    Homologene
    FAMILY microtubule associated protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text coexpressed with GABRR1
    basic FUNCTION
  • microtubule associated protein, involved in neurite outgrow
  • involved in the regulation of retrograde axonal transport of mitochondria
  • role in adapting microtubules for nerve cell-specific functions
  • plays a crucial role in cytoskeleton stability and may also have a role in other cellular functions
  • MAP1B-LC1 represses the transcriptional activity of TP53
  • contributes to the maintenance of microtubule dynamics
  • involved in microtubule assembly, an essential step in neurogenesis
  • implicated in regulating microtubule organization and
    • dynamics and neuronal polarization
  • MAP1B RNA forms an intramolecular G quadruplex structure, which is bound with high affinity and specificity by the FMR1 RGG box
  • could be considered as a new protein involved in the terminal differentiation of odontoblasts
  • new and crucial function of MAP1B required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization
  • implicated in axonal growth and guidance
  • new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton
  • this activity of MAP1B could contribute to the regulation of synaptic activity and plasticity in the adult brain
  • have important roles in neuronal development, particularly during neuronal migration and axonogenesis
  • function of MAP1B is to suppress axon branching and enhance axon growth and that this is achieved by maintaining dynamic microtubule growth
  • plays an important role in the stability of the cytoskeleton and may have other cellular functions
  • neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments
  • novel function of MAP1B related with the control of small GTPases
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein complex that consists of a heavy chain and light chain (LC1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FMR1 (RNA target of FMR1)
  • PAFAH1B1 and participate in neuronal migration
  • myelin-associated glycoprotein (MAG) and stathmin-like 2 (STMN2)
  • glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  • MAP1B-LC1 an interacting partner of PES1 required for ribosome biogenesis and cell proliferation
  • Mapmodulin/leucine-rich acidic nuclear protein (ANP32A)
  • GABA(C) rho1 subunit
  • gigaxonin (GAN)
  • myelin-associated glycoprotein (MAG)
  • synuclein, alpha (SNCA)
  • Ras association (RalGDS/AF-6) domain family member 1 (RASSF1)
  • MAP1B, a microtubule stabilizing protein, and CLTC, the major component of the clathrin triskelion, are interaction partners for DST
  • may contribute to the spatiotemporal activation of the Rho-GTPases in dendritic spines by binding to the RAC1 and RhoA GEFs, TIAM1, and ARHGEF2
  • MARCH5 interacts with and ubiquitinates mitochondrial MAP1B LC1
  • MAP1B facilitates trafficking of SCNA8 to the neuronal cell surface
  • MAP1B interaction with the FW Domain of the autophagic receptor NBR1 facilitates its Association to the microtubule network
  • MAP1A and MAP1B interact with SNTA1 in the central and peripheral nervous system
  • interacts with a guanine exchange factor, termed TIAM1, which specifically activates RAC1
  • association between TULP1 and the microtubule-associated protein, MAP1B
  • MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway
    • cell & other
    REGULATION
    repressed by FMR1 (inhibition of microtubule -dependent synaptic growth and function)
    Other mitogen-activated protein kinase 8 (MAPK8) a critical regulator of MAP1B activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice carrying an insertion in Mtap1b gene die during embryogenesis. Heterozygotes mice exhibit slower growth rates, lack of visual acuity in one or both eyes, and motor system abnormalities. Histochemical analysis revealed abnormalities in Purkinje cell dendritic processes