Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GRIA1

contributors: mct/npt/pgu - updated : 27-09-2022

HGNC name	glutamate receptor, ionotropic, AMPA 1
HGNC id	4571

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IDLSE

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in cortex in FRAXA

Susceptibility

to psychotic bipolar disorder to diabetic retinopathy

Variant & Polymorphism other	variant increasing the risk of psychotic bipolar disorder
	GRIA1 (rs2195450) genes assolcitaed with diabetic retinopathy

Candidate gene	candidate gene for susceptibility to schizophrenia
Marker
Therapy target

ANIMAL & CELL MODELS

	deletion studies in mice where knockout models of the GluA1-encoding gene Gria1 have been established and report normal development and life expectancy in Gria1-/- animals (
	GluA1-knockout mice (Gria1-/-) displayed various circadian abnormalities, including misaligned, fragmented, and more variable rest-activity patterns