| Symbol
| CNR1
| contributors: mct/npt - updated : 09-07-2017
|
| HGNC name
| cannabinoid receptor 1 (brain)
|
| HGNC id
| 2159
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
in clear cell renal cell carcinoma  | | constitutional
|
|
| --over
|
| |
might cause abnormal decidualization and impair trophoblast invasion, thus being involved in the pathogenesis of preeclampsia | | constitutional
|
|
|
| loss of function
| |
alleviates diabetes-mediated renal deterioration | | constitutional
|
|
|
| loss of function
| |
combined deficiency of the CNR1 and CNR2 receptors protects against age-related bone loss by osteoclast inhibition | |
| Susceptibility
|
to anorexia nervosa to obesity related phenotypes to hebephrenic schizophrenia to sensitivity to the acute effects of cannabinoids on EP300 generation in healthy subjects to diabetic nephropathy and diabetic retinopathy in patients with T2DM |
| Variant & Polymorphism
other
| variant increasing the risk of obesity related phenotypes |
|
variant increasing the risk of hebephrenic schizophrenia |
|
variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on EP300 generation in healthy subjects |
|
association of the G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM |
|
|
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| osteoarticular | bone | | |
| treatment of osteoporosis and other bone diseases (antagonists of CNR1) | | digestive | | | |
| use of cannabinoid CB(1) receptors in parietal cells as new therapeutic targets for the regulation of gastric acid production | | diabete | type 1 | | |
| CNR1 inhibition may be beneficial in the treatment of diabetic retinopathy, a devastating complication of diabetes | | miscelleaneous | urinary | chronic kidney disease | |
| may be a new target for treating chronic kidney disease |
| | | |
|
| mice lacking the Cnr1 gene, showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal neurons in the hippocampus ( | |
|