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FLASH GENE
Symbol FPR1 contributors: mct - updated : 01-04-2014
HGNC name formyl peptide receptor 1
HGNC id 3826
DNA
TYPE functioning gene
STRUCTURE 6.12 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • a consensus binding site for the transcription factor SPI1
  • FPR1 promoter activity requires SPI1
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1334 - 350 - 1992 1373134
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
     female systemuterus   
    Respiratorylung    
    Visualeyelens    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Visualepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-terminal phosphorylation sites
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • secretin receptor superfamily
  • G-protein coupled receptor 1 family
  • formyl peptide receptor (FPR) family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating chemotaxis and inducing leukocyte activation
  • receptor for n-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors
  • novel role for FPR1 stimulation in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of RAC1 and CDC42
  • expression of FPR1 in myeloid cells is developmentally regulated
  • lens epithelial cell FPR1 may be involved in development and maintenance of the lens
  • role for FPR1 to chemotaxis and superoxide production of resting and pro-inflammatory M1 macrophages
  • fundamental difference between the two neutrophil FPR1 and FPR2, regarding their sensitivities to third intracellular loop pepducins
  • FPR1, FPR2, FPR3, are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FPR2 might exist as homo- or heterodimer with FPR1 or FPR3 (the two other family members) and operate in a ligand-biased fashion
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coupling with Gs alpha protein and activating adenylate cyclase, leukocyte membrane glycoprotein
  • possible signaling role for ANXA1 in mitogen-activated proliferation of breast tumor epithelial cells that is mediated via activation of FPR1 and FPR2
  • different structural determinants are used by FPR1 and FPR2 to interact with formyl peptides
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS