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FLASH GENE
Symbol MGAT1 contributors: mct/npt - updated : 01-08-2012
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
HGNC id 7044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • glycosyltransferase 13 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • involved in biosynthesis of complex Asn-linked (N) glycans
  • monoacylglycerol acyltransferase, catalyzing the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids
  • in the intestine, plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
  • controls complex and hybrid N-glycan synthesis
  • involved in dietary fat absorption
  • MGAT1-dependent N-glycans are essential for the normal development
  • increased PPARG and MGAT1 activity during a high-fat diet (HFD) plays a major role in developing hepatic steatosis by regulating fatty acid transport and the triglyceride (TG) incorporation pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text essential for normal embryogenesis, symetry breaking
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPARG directly regulates the MGAT1 promoter activity
  • directly regulated by PPARG and plays a role in regulating the pathway leading to incorporation of fatty acid into TG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inactivation of the MGAT1 gene in oocytes impairs oogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    metabolismlipid 
    inhibition of PPARG-induced MGAT1 for the alternative TG synthesis pathway would be one of the excellent therapeutic targets for hepatic steatosis
    ANIMAL & CELL MODELS
  • mutant Mgt1-/- have impaired neural tube formation,vascularizations and left-right (L/R asymetry)
  • null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities, and a severely reduced life span