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FLASH GENE

Symbol

MGAT1

contributors: mct/npt - updated : 01-08-2012

HGNC name	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
HGNC id	7044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.3      Physical location : 180.217.542 - 180.237.137
Synonym name	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
Synonym symbol(s)	NAGT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GGNT1
EC.number	2.4.1.101

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	19.60 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

housekeeping gene

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	All variants encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002406 2 - 2937 NP_002397 50.8 445 - 2007 17716624 NM_001114618 3 - 3181 NP_001108090 50.8 445 - 2007 17716624 NM_001114617 3 - 3095 NP_001108089 50.8 445 - 2007 17716624 NM_001114619 2 - 2658 NP_00110809 50.8 445 - 2007 17716624 NM_001114620 2 - 2869 NP_001108092 50.8 445 - 2007 17716624

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Lymphoid/Immune spleen       highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

glycosyltransferase 13 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	involved in biosynthesis of complex Asn-linked (N) glycans
	monoacylglycerol acyltransferase, catalyzing the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids
	in the intestine, plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
	controls complex and hybrid N-glycan synthesis
	involved in dietary fat absorption
	MGAT1-dependent N-glycans are essential for the normal development
	increased PPARG and MGAT1 activity during a high-fat diet (HFD) plays a major role in developing hepatic steatosis by regulating fatty acid transport and the triglyceride (TG) incorporation pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	essential for normal embryogenesis, symetry breaking

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PPARG directly regulates the MGAT1 promoter activity
	directly regulated by PPARG and plays a role in regulating the pathway leading to incorporation of fatty acid into TG

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function inactivation of the MGAT1 gene in oocytes impairs oogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed metabolism lipid   inhibition of PPARG-induced MGAT1 for the alternative TG synthesis pathway would be one of the excellent therapeutic targets for hepatic steatosis

ANIMAL & CELL MODELS

	mutant Mgt1-/- have impaired neural tube formation,vascularizations and left-right (L/R asymetry)
	null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities, and a severely reduced life span