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FLASH GENE

Symbol

HAPLN1

contributors: mct/npt - updated : 19-01-2010

HGNC name	hyaluronan and proteoglycan link protein 1
HGNC id	2380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the majority of mesotheliomas (Ivanova 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	targeting the SP-IgV domain may be one of the therapeutic approaches in mesothelioma treatment (Ivanova 2009)

ANIMAL & CELL MODELS

Crtl1-deficient mouse revealed a spectrum of cardiac malformations, including AV septal and myocardial defects, while expression studies showed a significant reduction in versican levels (Wirrig 2007)