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FLASH GENE

Symbol

IL6ST

contributors: mct/ - updated : 13-09-2017

HGNC name	interleukin 6 signal transducer (gp130, oncostatin M receptor)
HGNC id	6021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	59.90 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	with an alternatively spliced secreted form

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002184 17 - 9071 NP_002175 - 918 - 2007 17436251 NM_175767 16 - 8988 NP_786943 - 329 - 2007 17436251 NM_001190981 16 - 8888 NP_001177910 - 857 - 2000 10675624

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Hearing/Equilibrium ear inner cochlea   highly Nervous nerve       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytokine binding domain (CBD)
	two fibronectin III domains linked by a proline-rich sequence: N-terminal fibronectin III domain of the CBD characterized by two conserved disulfide bridges
	C-terminal fibronectin III domain of the CBD with a conserved WSXWS motif
	intracellula
	N-glycosylation of the extracellular domains D1-D3 has been shown to be dispensable for binding of the IL6ST ligand IL-6 and its cognate receptor
	box 1 and box 2-like motifs conserved in cytokine receptors

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

class I hematopoietin receptor family

CATEGORY

signaling hormone cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein, cholesterol enriched membrane microdomains (rafts)

basic FUNCTION	interleukin 6, signal transducer (GP130), needed for IL6R activity and signal transduction of the IL-6 related cytokines mediated by JAK kinases
	IL6 and IL6ST may enhance pain not only indirectly through their proinflammatory actions but also through a direct action on nociceptors
	its activation in photoreceptors had potentially a general protective role independent of whether stress was caused by light or genetic mutations
	shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component	common transducing component for IL6RA, LIFR, CNTFR, CSF3R (see symbols)
	component of microdomains rafts
	heterodimerizing with OSMR
	quaternary cytokine receptor complex consisting of IL6ST, LIFR, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTFRA)

INTERACTION

DNA

RNA

small molecule

protein	shared receptor for at least nine cytokines and can signal either as a homodimer or as a heterodimer with Leukemia Inhibitory Factor Receptor (LIFR)
	MTRNR2L1 inhibits neuronal cell death and dysfunction by binding to a novel IL6-receptor-related receptor(s) on the cell surface involving CNTFR, IL27RA, and IL6ST
	interacting with Sortilin
	excessive CXCL1 expression in IL6ST-deficient endothelial cells augments neutrophil adhesion but hinders migration, most likely by disrupting chemotactic gradients
	TRAF5 binds to the signal-transducing receptor IL6ST through the C-terminal TRAF domain and inhibits Th17 development mediated by IL6

cell & other

REGULATION

Other

regulated by N-linked glycosylation that is required for the stability but not the signal-transducing function

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS