Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LPA contributors: mct - updated : 23-04-2008
HGNC name lipoprotein, Lp(a)
HGNC id 6667
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten types of cysteine-rich, kringle KIV modules, one of which KIV-2 occuring in variable number, from 2 to >40
  • a protease domain (peptidase S1 domain)
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to PLG
    Homologene
    FAMILY peptidase S1 family, plasminogen subfamily
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
    text plasma
    basic FUNCTION
  • protease, potential modulator of blood-clotting process
  • having serine proteinase activity, and being able of autoproteolysis
  • playing a crucial role in the maintenance of hair growth
  • association of CCL2 with OLR1 and LPA may play a role in modulating monocyte trafficking during atherogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Lpa is a complex of apoliprotein and one glycoprotein both linked by a single disulfide
    • INTERACTION
    DNA
    RNA
    small molecule
    protein receptor P2RY5
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LPA
    Susceptibility
  • to IDDM (IDDM8)
  • to severe coronary artery disease (CAD)
    • Variant & Polymorphism SNP , other
  • affecting plasma concentration of LPA
  • I4399M SNP is associated with severe CAD and plasma lipoprotein(a) levels
  • four SNPs overlapping the SLC22A3-LPAL2-LPA gene cluster associated to risk of coronary artery disease (Tregouet 2009)
    • Candidate gene
    Marker
    Therapy target therapeutic approaches in the treatment of hair loss
    ANIMAL & CELL MODELS