Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LPA

contributors: mct - updated : 23-04-2008

HGNC name	lipoprotein, Lp(a)
HGNC id	6667

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument hair follicle cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten types of cysteine-rich, kringle KIV modules, one of which KIV-2 occuring in variable number, from 2 to >40
	a protease domain (peptidase S1 domain)

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to PLG

Homologene

FAMILY

peptidase S1 family, plasminogen subfamily

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
text	plasma

basic FUNCTION	protease, potential modulator of blood-clotting process
	having serine proteinase activity, and being able of autoproteolysis
	playing a crucial role in the maintenance of hair growth
	association of CCL2 with OLR1 and LPA may play a role in modulating monocyte trafficking during atherogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

Lpa is a complex of apoliprotein and one glycoprotein both linked by a single disulfide

INTERACTION

DNA

RNA

small molecule

protein

receptor P2RY5

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LPA

Susceptibility

to IDDM (IDDM8) to severe coronary artery disease (CAD)

Variant & Polymorphism SNP , other	affecting plasma concentration of LPA
	I4399M SNP is associated with severe CAD and plasma lipoprotein(a) levels
	four SNPs overlapping the SLC22A3-LPAL2-LPA gene cluster associated to risk of coronary artery disease (Tregouet 2009)

Candidate gene
Marker
Therapy target	therapeutic approaches in the treatment of hair loss

ANIMAL & CELL MODELS