Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RING1

contributors: mct - updated : 01-02-2019

HGNC name	ring finger protein 1
HGNC id	10018

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RING zinc finger, RING domain required for its E3 Ub ligase activity

HOMOLOGY

interspecies	ortholog to murine Ring1
	homolog to Drosophila Ring
	homolog to C.elegans K01A2.7

Homologene

FAMILY	polycomb group (PcG) family
	RING finger family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as a transcriptional repressor
	involved in maintaining the transcriptionnally repressive state of genes
	modifing chromatin and rendering it heritably changed in its expressibility
	critical role for BMI1 and RING1 in H2A ubiquitylation and HOX gene silencing
	expanded regulatory role for RING1, RNF2 proteins in the epigenetic regulation of gene expression
	crucial role for RING1-dependent repression of MEIS2 and likely also MEIS1 for distal specification
	RING1 is deregulated in myelodysplastic syndromes (MDS) and plays a role in the erythroid development defect
	is an E3-ubiquitin ligase that is involved in epigenetic control of transcription during development

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	transcriptional repressor

PATHWAY

metabolism

signaling

a component

associating and colocalizing with the multimeric chromatin-associated polycomb (PcG) group protein complex

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein	binding to SSX1 and SSX2
	during transdifferentiation, innate immune activation increases NOS2 generation of NO to S-nitrosylate RING1, a key member of the polycomb repressive complex
	binding to polycomb group proteins BMI1, EDR1, CBX4
	during transdifferentiation, innate immune activation increases NOS2 generation of NO to S-nitrosylate RING1, a key member of the polycomb repressive complex
	RING1 interacted with BSG through the transmembrane domain (RING1 inhibits BSG capability promoting melanoma cell migration)
	RING1 acts as an E3 ubiquitin (Ub) ligase to directly interact with and ubiquitinate TP53, resulting in its proteasome-dependent degradation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in neurodevelopmental syndrome, and mutation of RING1 can disrupt histone H2A ubiquitylation without disrupting RING1 catalytic activity

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	expression of RING1 protein may be a novel indicator of hepatocellular carcinoma prognosis
Therapy target

ANIMAL & CELL MODELS