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FLASH GENE
Symbol RING1 contributors: mct - updated : 01-02-2019
HGNC name ring finger protein 1
HGNC id 10018
Location 6p21.32      Physical location : 4.408.512 - 33.180.498
Synonym name DNA segment, single copy,probe 33X1 (RING1)
Synonym symbol(s) D6S111E, RNF1, RING1A
EC.number 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 4.21 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - COL11A2 - RXRB - SLC39A7 - HSD17B8 - RING1 - RPS18 - HKE2 - RGL2 - cen
Authors Kikuti (97)
regionally located mapped to the HLA class II region contiguous with the RING finger genes FABGL and HKE4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1741 - 406 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING zinc finger, RING domain required for its E3 Ub ligase activity
    • HOMOLOGY
    interspecies ortholog to murine Ring1
    homolog to Drosophila Ring
    homolog to C.elegans K01A2.7
    Homologene
    FAMILY
  • polycomb group (PcG) family
  • RING finger family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor
  • involved in maintaining the transcriptionnally repressive state of genes
  • modifing chromatin and rendering it heritably changed in its expressibility
  • critical role for BMI1 and RING1 in H2A ubiquitylation and HOX gene silencing
  • expanded regulatory role for RING1, RNF2 proteins in the epigenetic regulation of gene expression
  • crucial role for RING1-dependent repression of MEIS2 and likely also MEIS1 for distal specification
  • RING1 is deregulated in myelodysplastic syndromes (MDS) and plays a role in the erythroid development defect
  • is an E3-ubiquitin ligase that is involved in epigenetic control of transcription during development
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
  • associating and colocalizing with the multimeric chromatin-associated polycomb (PcG) group protein complex
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to SSX1 and SSX2
  • during transdifferentiation, innate immune activation increases NOS2 generation of NO to S-nitrosylate RING1, a key member of the polycomb repressive complex
  • binding to polycomb group proteins BMI1, EDR1, CBX4
  • during transdifferentiation, innate immune activation increases NOS2 generation of NO to S-nitrosylate RING1, a key member of the polycomb repressive complex
  • RING1 interacted with BSG through the transmembrane domain (RING1 inhibits BSG capability promoting melanoma cell migration)
  • RING1 acts as an E3 ubiquitin (Ub) ligase to directly interact with and ubiquitinate TP53, resulting in its proteasome-dependent degradation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in neurodevelopmental syndrome, and mutation of RING1 can disrupt histone H2A ubiquitylation without disrupting RING1 catalytic activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression of RING1 protein may be a novel indicator of hepatocellular carcinoma prognosis
    • Therapy target
    ANIMAL & CELL MODELS