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FLASH GENE

Symbol

HSPA1L

contributors: mct - updated : 21-04-2008

HGNC name	heat shock 70kDa protein 1-like
HGNC id	5234

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	5.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	see HTFAG@ & HSPA1A

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 2550 - 641 - Afzal (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland   highly   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION

basic FUNCTION	acting as a molecular chaperone
	might be implicated in the development of schizophrenia
	influence cytokine concentrations and interfere with outcome after major injury
	not heat inducible (Konings 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Susceptibility

to noise-induced hearing loss (NIHL)

Variant & Polymorphism	SNP rs2227956 resulted in a significant association with NIHL (Konings 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS