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FLASH GENE
Symbol HSPA1L contributors: mct - updated : 21-04-2008
HGNC name heat shock 70kDa protein 1-like
HGNC id 5234
Location 6p21.3      Physical location : 3.062.983 - 31.782.835
Synonym name heat shock 10kDa protein 1-like
Synonym symbol(s) HSP70-1L, HSP70-HOM, HSP70T, hum70t
DNA
TYPE like-sequence
STRUCTURE 5.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map see HTFAG@ & HSPA1A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2550 - 641 - Afzal (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • acting as a molecular chaperone
  • might be implicated in the development of schizophrenia
  • influence cytokine concentrations and interfere with outcome after major injury
  • not heat inducible (Konings 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility to noise-induced hearing loss (NIHL)
    Variant & Polymorphism SNP rs2227956 resulted in a significant association with NIHL (Konings 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS