Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HIVEP1 contributors: mct/npt/pgu - updated : 12-05-2013
HGNC name human immunodeficiency virus type I enhancer binding protein 1
HGNC id 4920
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sets of two zinc fingers being widely separated
  • a fifth zinc finger in-between (C2H2 type, Krüppel-like)
  • ZAS1 and ZAS2 motifs
  • eight T/SPRX/K motifs
    • HOMOLOGY
    interspecies ortholog to murine Hivep1
    homolog to Drosophila shn
    homolog to C.elegans R11A8.7B
    intraspecies paralog to HIVEP2,HIVEP3
    Homologene
    FAMILY
  • Schnurri protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text nucleolar protein
    basic FUNCTION
  • involved in transcriptional activation and repressing C-myc transcription
  • inducing mitochondrial involvement in the apoptotic process
  • participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions
  • directly participate in the transcriptional regulation of a variety of genes by binding to their promoter NF-KB consensus sequences
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to enhancer MHC sequence
  • binding to a positive regulating domain of the IFN-beta promoter
  • binding to 5'-GGGACTTTCC-3' sequence which is found in the enhancer elements of numerous viral promoters such as those of SV40,CMV or HIV1
    • RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binding to MHC,positive regulatory domain II (HIV - EP1/MBP1/PRDII - BF1)
  • HIVEP1-CIRH1A interaction (CIRH1A up-regulates a canonical NF-kappaB element through strong interaction with HIVEP1)
  • TRAPPC2 interact with HIVEP1, a repressor of the MYC promoter (pMID: 24098805)
    • cell & other
    REGULATION
    induced by mitogen,serum,virus and phorbol ester
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to venous thrombosis
    Variant & Polymorphism other rs169713C allele associated with an increased risk for venous thrombosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS