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FLASH GENE

Symbol

DRD1

contributors: mct - updated : 12-01-2015

HGNC name	dopamine receptor D1
HGNC id	3020

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function reduces renal sodium reabsorption

Susceptibility

to schizophrenia (rs 4532) to bipolar disorder to alcoholism to nicotine dependence to autism spectrum disorder in male-only to blood pressure variation

Variant & Polymorphism other	5' UTR polymorphism associated with severity and temperament of alcoholism
	A48G polymorphism in the D1 receptor genes associated with bipolar I disorder
	polymorphisms increasing the risk of nicotine dependence
	haplotype increasing the risk of autism spectrum disorder in male-only
	DRD1 AGC haplotype associated with lower systolic (-3.54 mm Hg) and diastolic (-2.80 mm Hg)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS