Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DRD1 contributors: mct - updated : 12-01-2015
HGNC name dopamine receptor D1
HGNC id 3020
Location 5q35.2      Physical location : 174.867.675 - 174.871.163
Synonym name D(1A) dopamine receptor
Synonym symbol(s) DADR, DRD1A, D1R, DADRA
DNA
TYPE functioning gene
STRUCTURE 3.49 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - FLT4 /D5S211 - DRD1 - FGFR4 - D5S62 /D5S43 - qter
Authors Frolova (91), Warrington (92), Wetsbrook (92)
Text see D5S2360
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3373 - 446 - 2007 17310237
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiens
 brainbasal nucleicaudate nucleus  
Respiratoryrespiratory tractbronchus    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularsmooth    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a di-L motif at the C-terminus critical for the glycosylation and cell surface targeting of DRD1
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • dopamine receptor D1,adenylate cyclase stimulating
  • involved in the control of vascular tone
  • specific role in spinal network activation and rhythmic movement induction
  • is critical for spatial learning
  • plays a critical role in regulating blood pressure through its actions on renal hemodynamics and epithelial ion transport, which are highly linked to its intracellular trafficking
  • concerted action of NPPA and DRD1 to regulate sodium homeostasis in nephrotic syndrome
  • facilitates relaxation in airway smooth muscle
  • DRD1 regulates the activity-dependent development of retinal light responsiveness
  • potential roles of DRD1 in the activity-dependent functional development of retina
  • dentate gyrus DRD1, but not DRD5, contribute to the formation of distinct contextual representations of novel environments
  • differential roles of DRD1 and DRD2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calnexin interactions critically regulate DRD1
  • CALY interacting directly with DRD1, and is implicated in various neuropsychiatric disorders including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder
  • CALY interacts with DLG4 and subsequently forms a ternary complex with DRD1 through DLG4
  • interaction between DRD1 and NMDAR in synapses participate in the building of the dopamine-receptor-mediated signalling, and most likely to the glutamate-dopamine cross-talk
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    reduces renal sodium reabsorption
    Susceptibility
  • to schizophrenia (rs 4532)
  • to bipolar disorder
  • to alcoholism
  • to nicotine dependence
  • to autism spectrum disorder in male-only
  • to blood pressure variation
  • Variant & Polymorphism other
  • 5' UTR polymorphism associated with severity and temperament of alcoholism
  • A48G polymorphism in the D1 receptor genes associated with bipolar I disorder
  • polymorphisms increasing the risk of nicotine dependence
  • haplotype increasing the risk of autism spectrum disorder in male-only
  • DRD1 AGC haplotype associated with lower systolic (-3.54 mm Hg) and diastolic (-2.80 mm Hg)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS