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FLASH GENE

Symbol

DPEP1

contributors: mct - updated : 28-03-2019

HGNC name	dipeptidase 1 (renal)
HGNC id	3002

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q24.3      Physical location : 89.679.715 - 89.704.838
Synonym symbol(s)	RDP, MDP, MBD1
EC.number	3.4.13.19

DNA

TYPE	functioning gene
STRUCTURE	28.23 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001128141 11 - 1664 NP_001121613 - 411 - 2002 12144777 NM_004413 11 - 1752 NP_004404 - 411 - 2002 12144777

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Hearing/Equilibrium ear       predominantly Homo sapiens Respiratory lung         Homo sapiens Urinary kidney       highly Homo sapiens

cell lineage
cell lines
fluid/secretion	sreum, urine

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal signal peptide, a 22-amino acid signal peptide
	four potential N-glycosylation sites
	a GPI-acnhor
	a C-ter propeptide removed in the mature form

secondary structure

eight alplha helix and beta sheet pairs per subunit

conjugated

GlycoP , LipoP , MetalloP

mono polymer

homomer , dimer

isoforms

Precursor

a signal peptide from the 1st to the 16th aa

HOMOLOGY

Homologene

FAMILY

peptidase M19 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane,junction
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	attached to the membrane by a GPI-anchor
	brush border membrane

basic FUNCTION	hydrolyzing a wide range of dipeptides
	playing an important role in the regulation of leukotriene activity
	converting lekotriene D4 to leukotriene E4
	plays a role in pancreatic cancer aggressiveness
	functions as a positive regulator for colon cancer cell metastasis
	zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

metabolism of glutathione and its conjugates

a component

homodimer disulfide-linked

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	two ions Zn2+

protein

DPEP1 promotes cancer metastasis by regulating CDH1 plasticity

cell & other

REGULATION

inhibited by	by EEDQ and dansyl-ethylenediamine
	cilastatin

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancers (CRCs) and high DPEP1 expression levels are associated with poorer patient survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	excellent marker of high-grade intraepithelial neoplasia (IEN) and Colorectal cancer (CRC)
Therapy target
	System Type Disorder Pubmed cancer digestive colon it might be a potential therapeutic target for preventing the progression of colon cancer cancer endocrine pancreas DPEP1 may be a candidate target in PDAC for designing improved treatments

ANIMAL & CELL MODELS

Mbd1 deficient mice