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FLASH GENE

Symbol

IL9

contributors: mct - updated : 24-05-2016

HGNC name	interleukin 9
HGNC id	6029

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	3.58 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see IRF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed IL9 5 - 591 14.1 144 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine T cell growth factor P40
	homolog to C.elegans f28c6.10

Homologene

FAMILY

interleukin (IL-7/IL-9) family

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

determining factor in controlling bronchial hyperresponsiveness

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IL4, IL9, IL13 may increase CLCA1 expression in cystic fibrosis but may not have a significant effect on mucus expression
	SMAD2 and SMAD3 were redundantly essential for TGFB1 signaling to induce histone modifications for IL9 transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS