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FLASH GENE

Symbol

NPR3

contributors: mct/npt - updated : 16-01-2024

HGNC name	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
HGNC id	7945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BOMOS

Susceptibility

to cerebrovascular disease

Variant & Polymorphism other	NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	its complete absence, unexpectidly produces skeletal abnormalities in mice
	continuous infusion of the peptide Ostn, an endogenous ligand of Npr3 secreted by bone and muscle cells, lowered blood pressure in wild-type mice, suggesting that endogenous natriuretic peptides play major roles in the regulation of blood pressure