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Symbol NPR3 contributors: mct/npt - updated : 16-01-2024
HGNC name natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
HGNC id 7945
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one transmembrane segment (1TM) and
  • an intracellular domain, without guanylate cyclase activity
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • ANF receptor family, natriuretic peptides family
    • CATEGORY enzyme , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system
  • playing a role for in the regulation of glucagon secretion from human alpha cells (Burgess 2009)
  • NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF, which are regulators of apoptosis
  • anti-apoptosis role of NPR3 in protecting cardiomyocytes suggesting molecular link between natriuretic peptides (NPs) system and programmed cell death
  • NPR3 lacks the guanylate cyclase activity of NPR1 and NPR2 and is reportedly coupled to Gi-dependent signaling
  • plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor
  • regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein could interact with OSTN (modulating NPR3 actions on the skeleton) (Moffatt 2007)
  • OSTN binds to NPR3 competitively with NPPA and may affect NPPA concentrations in a local or systemic manner
  • role of NPR3 in anti-apoptosis via the breast cancer type 1 susceptibility protein (BRCA1) and TNF
  • OSTN binds to natriuretic peptide receptor 3 (NPR3) in periosteal osteoprogenitors, thereby preventing NPR3-mediated clearance of NPPC and consequently facilitating NPPC-signal-mediated bone growth
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BOMOS
    Susceptibility to cerebrovascular disease
    Variant & Polymorphism other
  • NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • its complete absence, unexpectidly produces skeletal abnormalities in mice
  • continuous infusion of the peptide Ostn, an endogenous ligand of Npr3 secreted by bone and muscle cells, lowered blood pressure in wild-type mice, suggesting that endogenous natriuretic peptides play major roles in the regulation of blood pressure