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FLASH GENE

Symbol

ANXA6

contributors: shn/npt - updated : 04-03-2020

HGNC name	annexin A6
HGNC id	544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   contributes to breast cancer progression by promoting the loss of functional cell-cell and/or cell-ECM contacts and anchorage-independent cell proliferation tumoral     --low   is specifically reduced in human hepatocellular carcinoma suggesting a role of this protein in hepatocarcinogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   annexin A6 can be exploited to inhibit chronic mechanical pain

ANIMAL & CELL MODELS

Annexin A6-deficient mice showed increased sensitivity to mechanical stimuli